I think the transit service's official route/system map is a good place to start, because it'll be instantly recognizable to your audience. Careful though, some transit services are
overly protective of their maps...
From there, I think it depends on the specifics you have to work with. I find that the most interesting infographics combine big-data quantitative stats with fine-grained qualitative stories. For example: Last year there were 63 Passenger Assistance Alarms at Main Street Station (big data). One of those, on April 8 was Alice who went into labour and later delivered a baby girl (fine-grain). It really depends on what information you have available to you. From there, you can make a decision on the best way to present it.
Hope that helps—in any case, I'm claiming the first comment prize!